The good news is that weight loss pills don’t need to have earth-shattering effects to improve your health. According to a study by Gerry Oster and other epidemiology researchers, a sustained 10% weight loss (which you could achieve by taking Alli for two years) would reduce your risk of heart disease and stroke and significantly increase your life expectancy (3).
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Where commercial weight loss programs go hands-on, the Mayo Clinic Diet goes streamlined. The vibrant, best-selling hardback (that looks a lot like a fun middle school health textbook) is the first resource for diet information, you can also employ the sleekly designed but minimalist app, plus a full website of tips, recipes, and workouts. Those patient enough to cycle through all of Mayo’s resources will find lots of solid health information.

There is some scientific legitimacy to today’s lower-carb diets: Large amounts of simple carbohydrates from white flour and added sugar can wreak havoc on your blood sugar and lead to weight gain. While avoiding sugar, white rice, and white flour, however, you should eat plenty of whole-grain breads and brown rice. One Harvard study of 74,000 women found that those who ate more than two daily servings of whole grains were 49 percent less likely to be overweight than those who ate the white stuff. Eating whole grains is not only one of many great ways to lose weight; it can also make you smarter.
Losing weight is hard. Losing weight and then keeping it off is even harder. Case in point: 74% of adults in the United States are overweight or obese, and weight loss is a $20 billion industry. All that said, if you're trying to slim down, there's no reason to lose hope. Plenty of studies show that lasting weight loss is not a myth. Work some of the 57 research-backed food, exercise, and lifestyle tips that follow into your routine, and watch the pounds start to come off.
Sure, there's your one friend who swears by the Taco Cleanse. And that other friend who ate nothing but broccoli soup for a month and dropped 20 pounds, found the love of her life, and got promoted at work. But before you start blending 80 stalks of broccoli into a cup or crunching your way through a crate of tacos, check out which diets are backed by science. Because don't you want to try one that will do the trick for you?
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